Neptune (Resident Evil)

Neptune is the code name for an experiment involving administering the T-Virus to an ordinary Great White shark. The result is a much larger, much more ferocious predator.

Playing as either character, it is much easier and safer to simply avoid these sharks. Instead simply run to the Control Room and activate the draining mechanism. This will render these sharks helpless, and you can choose to either leave them or put them out of their misery as they lay flapping around on the floor.