An enormous spider created by experimenting with the T-Virus on arachnids. These venomous eight-legged monsters can surprise you when they suddenly land in front of you with their ability to walk on walls and ceilings.
Their presence within a room can be known to you if you listen out for their low-bass thumping noise as the scurry around. Using the Shotgun or the Grenade Launcher are good choice when it comes to disposing of these.