James Marcus (Resident Evil Zero)

James Marcus was one of the head researchers for Umbrella, and also one of its original founders. James is responsible for creating the T-Virus by combining the newly discovered Progenitor (Mother) Virus with Leech DNA.

However, despite his breakthroughs in Virus research and the results he gained for the benefit of Umbrella, he was assassinated and his research was continued by two much younger researchers, namely William Birkin and Albert Wesker.