Giant Black Widow (Resident Evil Code: Veronica)

The mother of all Black Widows, this regular black widow is the loner who was trapped below the floor in the B.O.W. Room in the Antartic Facility. When the gas leak occured, it grew even more to amazing proportions.

You'll encounter this creature when playing as Chris, however the fight is not mandatory. You can simply avoid it while you get the necessary items and then leave. However, if you're determined to kill it, it can be done with whatever powerful weaponry you have on you, the Grenade Launcher is always good for a boss battle.